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KMID : 1059519910350010078
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Journal of the Korean Chemical Society
1991 Volume.35 No. 1 p.78 ~ p.84
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Synthesis of Enkephalin Aminopeptidase Inhibitors
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Moon Byung-Jo
Cha Jong-Won
Kwon Oh-Shin
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Abstract
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In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase have been synthesized. The peptides contain 3-amino-2-hydroxy amino acid as a zinc binding site and side chains of substrate pattern. The peptides were synthesized in solution by chain elongation from C-terminal end using DCC/HOBt as coupling reagent. The peptides are shown to have very strong inhibitory activity against enkephalin aminopeptidase.
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